Name：Genistein
CAS No.：446-72-0
Molecular formula：C15H10O5
Formula weight：270.237
Purity：HPLC≥98%
Package：20mg～kg brown glass bottle or other packinging
Appearance：powder
Test method：high performance liquid phase (HPLC) Mass spectrometry (Mass) nuclear magnetic resonance (NMR)
Plant source：soybean; soya
Storage conditions: store in a light-proof container, refrigerate or freeze for long-term storage.
Application: for research use only, not for medical diagnosis.
Note:
①the sample solution is now used.If special circumstances require preparation in advance, it is suggested to divide into independent packaging and freeze for storage (below -20℃), and then take out and thaw before use. The storage life is suggested to be less than two weeks.
②Can be customized according to the requirements of the research and development of a variety of types/specifications/purity reference
Genistein 98% also can supply large goods.
Genistein is used for anti-tumor, bacteriostasis, blood lipid lowering and estrogen like effects.
antitumor activity
Inhibit cell cycle: make cells stop and G2 / M phase; Inducing tumor cell apoptosis: Tongguang up regulates relevant Pro apoptotic genes and down regulates corresponding anti apoptotic genes to promote tumor cell apoptosis, so as to prevent and limit the occurrence of tumor;
Bacteriostasis
Its antibacterial mechanism is achieved by destroying the integrity of cell wall and cell membrane, inhibiting TCA cycle pathway and protein synthesis. This is consistent with Kim's view on the antibacterial mechanism of drugs [11]. Because genistein has physiological activities such as bacteriostasis and oxidation resistance, in terms of nutrition, if Gen is selected as food additive, it can play its dual role and has a very broad application prospect.
Estrogen like effect
Gen (genistein or genistein) and its aglycones are the highest content components in soybean isoflavones. The aglycone form of soybean isoflavones has higher activity than the glycoside form, especially the gen activity, which has the two-way regulation of phytoestrogen. MCF-7 cells are ER positive human breast cancer cell lines, which can be specifically regulated by estrogen or estrogen like substances and proliferate. Estrogen like increment is very sensitive, simple and easy, and can also distinguish agonists and antagonists. Therefore, it is widely used to quickly screen and evaluate phytoestrogens of environmental estrogens.
Studies have reported that Gen can stimulate the expression of estrogen regulatory genes like estrogen, suggesting that Gen can bind to estrogen receptor, not only produce anti estrogen like effect, but also show certain estrogen effect by activating estrogen response elements.
Other name：5-18-04-00594 (Beilstein Handbook Reference)|5,7,4'-trihydroxyisoflavone|4',5,7-trihydroxyisoflavone|Genistein|GeniVida|4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-|prunetol|EINECS 207-174-9|genisteol|Bonistein
