Name:Mangostin
CAS No.:6147-11-1
Molecular formula:C24H26O6
Formula weight：410.46
Purity：HPLC≥98%
Package：20mg～kg brown glass bottle or other packaging
Appearance：powder
Test method：high performance liquid phase (HPLC) Mass spectrometry (Mass) nuclear magnetic resonance (NMR)
Storage conditions: store in a light-proof container, refrigerate or freeze for long-term storage.
Application: for research use only, not for medical diagnosis.
Note:
①the sample solution is now used.If special circumstances require preparation in advance, it is suggested to divide into independent packaging and freeze for storage (below -240℃), and then take out and thaw before use. The storage life is suggested to be less than two weeks.
②Can be customized according to the requirements of the research and development of a variety of types/specifications/purity reference
other name :α-mangostin
Mangostin HPLC≥98% we also can supply large goods.
Mangostin is a terpenoid compound isolated from the shell of mangosteen, an evergreen tree of Garcinia in Garcinia family. It is insoluble in water and soluble in medium and low polar solvents such as n-hexane, chloroform and ethyl acetate.
Mangostin effect:
1.Antibacterial effect
At 100 μ M / ml, it has a high inhibitory effect on Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium and Bacillus subtilis, and its MIC is 12.5 ~ 50 μ g/Ml。 α- mangostin has strong antibacterial activity against methicillin and toluene penicillin sensitive Staphylococcus aureus. α- and β- Inverted twist has a strong inhibitory effect on Mycobacterium tuberculosis. At 5mg / ml, it has a high inhibitory effect on flocculent epidermal tinea, Alternaria alternata, Mucor, Rhizopus and thorn spore Xiaoke Yinhan, and its MIC is 1 ~ 5 μ pg/Ml。
2.Inhibition of cyclooxygenase
Cyclooxygenase is involved in a variety of pathophysiological processes. Its high expression plays an obvious role in promoting the occurrence and development of inflammation, pain, cardiovascular disease, Alzheimer's disease and cancer. γ- Inverted twist can bind to the active site of cyclooxygenase and completely inhibit the activity of cyclooxygenase. α- Inverted twist also inhibited the activity of cyclooxygenase, which could inhibit the concentration range and γ- Inverted twist element is similar. Inhibition of bird myoglobin kinase and camp dependent protein kinase in rat liver. Sphingomyelinase is a hydrolase of sphingomyelin, which is involved in the regulation of cell growth, differentiation and apoptosis. It is closely related to the occurrence of intestinal tumors. α- It can inhibit the activity of nerve sheath phospholipase.
3.Anticancer effect
α- mangostin is involved in various carcinogenic processes of protein kinase phosphorylation, including cancer cell proliferation, apoptosis, angiogenesis and metabolism, and has a certain inhibitory effect on tumor cells in vivo and in vitro. γ- Inverted twist can inhibit the production of active oxygen by mitochondrial catalase of U87MG and gbm8401 cells, so as to inhibit the growth of tumor cells and promote the apoptosis of cancer cells γ- Inverted twist can be used as a leading compound of antitumor drugs with great potential. A-twist can also inhibit the proliferation of human chondrosarcoma cells. α- and γ- The higher the content of mangosteen, the better the inhibitory effect of the same total extract on breast cancer cells. Inverted twist can change the cell morphology and DNA fragments of breast tumor cells.
4.Antioxidation
The oxidation of low density lipoprotein is very harmful to cardiovascular disease and other chronic diseases
5.Other research findings
α- mangostin has a significant effect on albinism in Canada; α-、γ- It also has anti-inflammatory, chemical hypoxia resistance, analgesic, hypoglycemic and other biological activities. Histamine, an inflammatory mediator, can induce allergic asthma and bronchospasm. α- Inverted twist is a selective and competitive antagonist of histamine H1 receptor. Serotonin 2A (5-HT2A) receptor is related to cardiovascular disease. 5-HT has strong functions of constricting blood vessels and promoting platelet aggregation. γ- Inverted twist can inhibit platelet aggregation. α- The effect of inverted twist on cell apoptosis provides a new way for leukemia immunotherapy. The biological effects of phytoestrogens are mainly related to hormone related diseases, such as breast cancer, cardiovascular disease, osteoporosis, menopausal syndrome and so on. α- Inverted twist has therapeutic effect on hormone related diseases.
【 Application of mangostin]
Because of its antioxidant, anti-inflammatory, antibacterial, anticancer and other pharmacological activities, it is widely used in medicine, functional health products, food additives, beverages and cosmetics, mainly in medicine. The principle is as follows:
α- mangostin is a kind of oxaanthrone. It has anticonvulsant, antimutagenic, anti-inflammatory, anti-tumor, antioxidant and diuretic activities. It is used to help reduce gastrointestinal disorders, skin disorders, inflammation, infectious disease symptoms and reduce cholesterol levels. Oxaanthrone has strong antioxidant capacity and can significantly inhibit the formation of myocardial infarction or cerebral infarction; It can effectively inhibit the oxidation of low density lipoprotein (LDL) caused by free radicals and reduce the harm of heart diseases, such as atherosclerosis. The antioxidant properties of oxaanthrone are also reflected in its chemoprevention of cancer. Research shows that natural α- Inverted twist is covered with 7,12-dimethylbenzene（ α-) Anthracene can inhibit the early pathological changes of mammary organs in experimental rats α- Inverted twist showed strong chemopreventive effect in the biological identification of short-term colon cancer; 6 kinds of oxaanthrone isolated from mangosteen peel could inhibit human leukemia cell HL60, of which 10 μ Mol α- By inducing programmed cell death, inverted twist ketone showed complete inhibition on HL60. In addition, it also had anti-bacterial and antifungal activities and strong anti tuberculosis ability.
